The activation of PI3K/AKT pathway has been observed in most non-small cell lung cancer, which promotes proliferation, migration, invasion and drug resistance [31]; In view of the fact that FAM83B can be involved in activating PI3K/AKT/mTOR signal pathway, we detected the key signal molecules of PI3K/AKT pathway in H1299/FAM83B OE cells. This evidence concerns the gene SACK1B and non-small cell lung carcinoma.