Strikingly, l-fuc-triggered tumor suppression was associated with increases in intratumoral CD4+ T central and effector memory subpopulations that were abrogated by FTY720 (Fig. 2a,c (blue dashed boxes) and Supplementary Table 1), consistent with the role that PKA plays in regulating memory phenotype in T cells17. Here, CD4 is linked to neoplasm.