Oral l-fuc administration increased tumor fucosylation (approximately twofold), reduced tumor growth (~50%) and increased total itICs (~10–50-fold) (including CD3+ (CD4+ and CD8+) T, natural killer (NK), macrophage, dendritic cell (DC) and myeloid-derived suppressor (MDSC)-like cell subpopulations, without altering splenic lymphocyte profiles) (Extended Data Fig. 1a, Fig. 1a,b and Extended Data Fig. 1b,c, respectively). Here, CD4 is linked to neoplasm.