CD8A and infection: First, CD8+ depletion affects infection dynamics in early infection, leading to a higher fraction of short-lived productively infected cells at the time of treatment (48.7% for control group, 71.4% and 76.0% for pre-infection and pre-ART depletion, respectively; P < 0.001 for comparison of control and each treated group) (Extended Data Fig. 8a).