The same principle might apply to the observations that ectopic ACTH production can be associated with a variety of molecular genetic alterations including EWSR1::BEND2 and other gene fusions as in our cases, BCOR mutation as in one reported typical pulmonary carcinoid [14], and EWSR1::ETS fusions as in two recently reported Ewing sarcoma cases [33, 34]. Here, POMC is linked to Ewing sarcoma.