Although it is not clear, if the two different fusions EWSR1::BEND2 and KMT2A::BCOR might have functional relationship and hence represent two mutually exclusive alternate molecular pathomechanisms in ACTH-producing pancreatic NETs, it is noteworthy that two of the reported EWSR1::BEND2-rearranged astroblastoma-like gliomas expressed BCOR by immunohistochemistry, despite the absence of molecular BCOR alterations [20]. Here, POMC is linked to central nervous system cancer.