A meta-analysis conducted in a first-line setting of NSCLC with a high PD-L1 showed a pooled OS HR comparing single-agent ICI versus chemotherapy of 0.59 (95% CI 0.50–0.69) for men and only 0.84 (95% CI 0.64–1.10) for women [17]. Here, CD274 is linked to non-small cell lung carcinoma.