The top 10 genes that are altered among RET fusion-positive NSCLC cases are TP53 (43%), CDKN2A (29%), CDKN2B (23%), SETD2 (11%), MDM2 (10%), MYC (10%), MTAP (8%), NKX2-1 (7%), NFKBIA (5%), and CDK4 (5%). The gene discussed is SETD2; the disease is non-small cell lung carcinoma.