In several NCs, including TC-797 (BRD4-NUT+, thymus), PER-403 (BRD4-NUT+, lung), 1015 (BRD4-NUT+, lung), and tumor tissue from which 1015 was derived, massive hyperacetylated domains were observed that encompass many regulatory genes including ALX114. Here, BRD4 is linked to neoplasm.