Although it has been reported that the F1c region in NUT of BRD4-NUT interacts with the TAZ2 domain of p300 (Fig. 1a)13, the structural and molecular details of the F1c/TAZ2 interaction and its relation to p300 activation, histone hyperacetylation, and aberrant gene transcription for NUT carcinoma cell proliferation have remained elusive13. Here, EP300 is linked to nut midline carcinoma.