Notably, consistent with the previous report that histone deacetylase inhibitors (HDACis) suppress NC tumor growth in mice41, we found that HDACis (SAHA, TMP269 or LMK235) dispersed BRD4-NUT nuclear puncta in LO2 cells overexpressing EGFP-BRD4-NUT-WT shortly after the drug treatment (12 h), but the BRD4-NUT puncta formation recurred over time (48 h) (Supplementary Fig. 5c). Here, BRD4 is linked to neoplasm.