As a result, the only “true” interactor that was involved in two of three identified pathways, MET RECEPTOR ACTIVATION and SIGNALING BY MST1 (Table 2) which also had the highest log2FC in pull-down assay but no significantly different abundance between MCF7-COMT vs. MCF7-GFP cells (Fig. 6), was SPINT2, a protease inhibitor known for a negative regulation of hepatocyte growth factor-induced invasion in BC cells26. This evidence concerns the gene COMT and breast cancer.