Here we study its role in the model of ER dependent breast cancer subtype, luminal A. Using invasion studies in 2D and 3D setting we show that COMT overexpression is connected with lower invasiveness, being supported by RNA-Seq and DIA-based proteomics analysis12 recognizing changes relevant for organization of extracellular matrix, MET signaling, and transcription. The gene discussed is COMT; the disease is breast cancer.