Recent studies also demonstrated that the expression of Tnfrsf12a is markedly elevated in hepatic progenitor cells in mouse models of cholestasis induced by BDL operation and 5-diethoxycarbonyl-1,4- dihydrocollidine (DDC) diet [22, 23], implying its distinct role in cholestatic liver injury. This evidence concerns the gene TNFRSF12A and cholestasis.