However, liver histology stained with H&E showed no significant difference in necrotic infarction between BDL-Tnfrsf12a KO and BDL-WT mice, although histologic scores of liver fibrosis, inflammation, and bile-duct proliferation were significantly decreased in BDL-Tnfrsf12a KO compared to BDL-WT mice (Fig. 2A, B). The gene discussed is TNFRSF12A; the disease is Hepatic fibrosis.