In A-KO mice, in addition to decreased expression of liver fibrosis-related genes, the Ripk3 and Tnf genes, as well as RIPK3 protein expression and RIPK3 and MLKL phosphorylation, were decreased compared with control mice (Fig. 9d–f, Supplementary Fig. 9f). The gene discussed is TNF; the disease is Hepatic fibrosis.