In lung cancer and esophageal squamous cell carcinoma cells, UBE2M knockdown disturbs cell cycle progression by triggering G2 phase cell cycle arrest, specifically by inhibiting cullins neddylation and upregulating CRL substrates (p21, p27, and Wee1) [55, 56]. The gene discussed is UBE2M; the disease is esophageal squamous cell carcinoma.