NR1H3 and coronary artery disorder: In a recent study, Wang et al.1 discovered that inhibition of asialoglycoprotein receptor 1 (ASGR1) (a GWAS identified gene associated coronary artery disease) could upregulate ABCG5, ABCG8, and ABCA1 by increasing LXRα, but inhibiting SREBP1, which is distinguished from canonical LXRα activation by pharmacological activators.