The authors’ investigation indicated that miR-34a ameliorates abnormal RA-FLS proliferation and inflammation by targeting cyclin I and further activating ATM/ATR/p53 signaling.109 Moreover, miR-20a, miR-15a/16 and miR-3926 negatively regulate the aggressive behavior of RA-FLSs and synovial inflammatory infiltration. The gene discussed is ATR; the disease is rheumatoid arthritis.