The authors also revealed that FoxC1 interacts directly with β-catenin to activate the canonical Wnt signaling pathway.99 In addition, differential expression of both miR-9 and miR-106b in RA-FLSs leads to shifts not only in the invasive properties of RA-FLSs but also in RANKL levels, which affects osteoclastogenesis.100,101. The gene discussed is TNFSF11; the disease is rheumatoid arthritis.