MiR-146a, a well-described epigenetic regulator in immune cells, is also expressed at high levels in RA-FLSs upon stimulation with proinflammatory stimuli such as IL-1β.80 It was proposed that miR-146a orchestrates the inflammatory response, suppressing the proliferation, changing the metabolic state and restricting the osteoclastogenic potential of RA-FLSs. The gene discussed is IL1B; the disease is rheumatoid arthritis.