Augmented miR-223 expression mediates the inhibition of Pknox1 and further fosters M2 polarization.132 Moreover, nucleotide-binding domain-(NOD)-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome activity, which is reported to be associated with the initiation, progression and perpetuation of RA, is negatively controlled by miR-223 in macrophages, leading to decreased IL-1β production.133 However, an opposing perspective was raised by Ogando and coworkers. Here, NLRP3 is linked to rheumatoid arthritis.