RAB5A and rheumatoid arthritis: Rosa et al. noted impaired miRNA biogenesis in neutrophils from RA patients, as reflected by a global decline in miRNA levels that led to the pathogenic activation of neutrophils.177 Typically, Murata et al. reported that decreased expression of miR-451 in RA neutrophils contributes to their chemotaxis toward inflammation sites, which is induced by 14-3-3ζ- and Rab5a-mediated p38 MAPK phosphorylation.