STAT3 and rheumatoid arthritis: Najm et al. demonstrated the anti-inflammatory and anti-erosion role of miR-17-5p in both RA-FLSs and CIA mice, which was associated with reduced IL-6 secretion, decreased immune cell infiltration and osteoclastogenesis inhibition through the JAK1-STAT3 pathway.93 Lin et al. concluded that low miR-22 levels in RA-FLSs enhance the expression of cysteine-rich protein 61 (Cyr61), which is a component of the ECM, contributing to synovial hyperplasia and pannus formation.