The NF-κB-directed activation of these miRNAs downregulates the expression of certain monocyte-specific and immunomodulatory genes, mediating proper osteoclast differentiation.187 Of note, contradictory outcomes emerged when validating the efficacy of these two NF-κB-associated miRNA clusters in animal models of RA. The gene discussed is NFKB1; the disease is rheumatoid arthritis.