TNF and rheumatoid arthritis: The expression levels of osteoclast-specific genes and NFATc1 protein were reduced in miR-124 mimic-transfected osteoclasts.194 Miller et al. demonstrated that miR-182 is also a negative regulator of TNF-α-mediated osteoclastogenesis via regulation of Foxo3 and Maml1, which may reveal an effective therapeutic approach in RA.195 More in vivo experimental evidence is still urgently needed for translation of relevant miRNA-related strategies into the clinic.