Patients with RA often have enhanced Th17 cell differentiation, which is at the expense of Treg differentiation, and these integrated changes favor systemic inflammation in RA.5,20,153 Jarid2 is a DNA-binding protein that recruits Polycomb repressive complex 2 (PRC2) to bind to chromatin and hence mediates silencing of cytokine genes in Th17 cells. Here, JARID2 is linked to rheumatoid arthritis.