Hyperplastic pannus nourished by neovascularization is a hallmark of RA, and prior research has revealed coupling of osteogenesis and angiogenesis.204 Due to the direct interaction of miR-590-3p with IL-18 mRNA, a low level of miR-590-3p in osteoblasts upregulates IL-18 expression and subsequently promotes the migration and tube formation of endothelial progenitor cells (EPCs).203 In addition, as Cyr61 is abundantly expressed in the synovial fluid of RA patients. The gene discussed is CCN1; the disease is rheumatoid arthritis.