Clinical evidence has demonstrated that the NLRP3 inflammasome plays a crucial role in multifarious diseases, including RA.140,141 Further studies revealed that the NLRP3 expression level was associated with clinical arthritis severity and the extent of radiological destruction.142,143 In particular, activation of the NLRP3 inflammasome occurs mainly in the monocyte-macrophage lineage.144 The miRNAs that participate in RA pathogenesis through NLRP3 inflammasome activation have been broadly researched. The gene discussed is NLRP3; the disease is rheumatoid arthritis.