WNT3A and arthritic joint disease: Injection of chemically modified miR-708-5p mimics into the tail vein of rats with CIA ameliorated arthritis scores and ankle histopathology by blocking Wnt3a/β-catenin signaling activation.278 In contrast, intravenous administration of an miR-145-5p agomir resulted in reduced OPG expression in ankle joints and a consequent increase in the severity of joint structural destruction in mice with CIA.192 Moreover, CIA mice injected intravenously with an miR-34a antagomir exhibited improved arthritis phenotypes and symptoms, accompanied by a restored Treg proportion.165