IL18 and rheumatoid arthritis: Hyperplastic pannus nourished by neovascularization is a hallmark of RA, and prior research has revealed coupling of osteogenesis and angiogenesis.204 Due to the direct interaction of miR-590-3p with IL-18 mRNA, a low level of miR-590-3p in osteoblasts upregulates IL-18 expression and subsequently promotes the migration and tube formation of endothelial progenitor cells (EPCs).203 In addition, as Cyr61 is abundantly expressed in the synovial fluid of RA patients.