After exosomes are taken up by RA-FLSs, the high abundance of exosomal miR-320a substantially restricts the invasive properties of RA-FLSs through interaction of miR-320a with CXCL9.224 MiR-150-5p expression in FLSs of RA patients was found to be decreased compared with that in FLSs of OA patients. This evidence concerns the gene CXCL9 and rheumatoid arthritis.