AIA mice injected intra-articularly with an miR-132 antagomir demonstrated a significant reduction in the number of periarticular osteoclasts.188 Consistent with the in vitro identification of the miR-141-3p/FoxC1/β-catenin axis regulating the pathological behaviors of RA-FLSs, manipulation of miR-141-3p overexpression in the joint cavity suppressed the expression of FoxC1 and β-catenin in the CIA rat model. This evidence concerns the gene FOXC1 and rheumatoid arthritis.