MMP14 and rheumatoid arthritis: Exosomal miR-150-5p negatively regulated MMP14 and VEGF, contributing to suppression of the migration and invasion of RA-FLSs and the decreased tube formation by HUVECs.225 Coincubation of exosomes derived from human MSCs with miR-124a overexpression with RA-FLSs resulted in a significant decline in the number and reduced migration of RA-FLSs.226 However, the underlying mechanisms and targets of exosomal miR-124a in the modulation of the aggressive behavior of FLSs in RA were not elucidated in this work.