Specifically, in an IRBP-TCR Tg model of spontaneous autoimmune uveitis (EAU), in which there are ~ 30% IRBP-TCR specific CD4 T cells, it has been proposed that IOI is caused by antigen-specific T cells activated in the bowel by IRBP/commensal-antigen cross-reactive peptides. Here, CD4 is linked to autoimmune uveitis.