IL2 and systemic lupus erythematosus: We next investigated the therapeutic potential of L72-FSY and its PEGylated form versus that of WT-IL-2 in a pristane-induced lupus model in B-hIL2RA mice as previously reported.49 The establishment of pristane-induced lupus was confirmed by the detection of proteinuria two months after pristane injection, and lupus mice were then randomly divided into five groups.