This result was consistent with a previous study demonstrating that long-term WT-IL-2 treatment resulted in the clinical and histological amelioration of lupus nephritis by reducing the activity and proliferation of both Tconv cells and Tregs.50 The decreases in hyperactivity and the number of Teff cells were probably due to the immunoregulatory effects of Tregs and associated with the progression of disease, which led to a compensatory reduction in the number of Tregs. Here, IL2 is linked to lupus nephritis.