Our results with AML 12 cells indicate that mTORC1 activation upon palmitate treatment downregulated the expression of autophagy genes Atg7 and Beclin1 and increased the accumulation of autophagic cargo SQSTM1/p62, thereby suggesting the autophagic blockade in lipotoxic AML 12 cells. This evidence concerns the gene SQSTM1 and acute myeloid leukemia.