Inhibition of G9a using G9a-specific inhibitor UNC-0642 (10 μM) in lipotoxic AML 12 cells restored the expression of Atg7 and Beclin1 protein levels (Fig. 6, H–J) and reduced H3K9me2 levels at the promoter regions of Atg7 and Beclin1 (Fig. 6, K and L). The gene discussed is EHMT2; the disease is acute myeloid leukemia.