The significantly higher level of CA-125 in severe and mild PE in comparison with the control group (p<0.001) which was observed in the current study, coinciding with many previous studies [21, 23, 28] in which some authors suggested that CA-125 is a promising biochemical marker and can reflect the severity of preeclampsia [18, 21, 23, 28, 41]. Here, MUC16 is linked to preeclampsia.