DIAPH2 and nodular sclerosis classical Hodgkin lymphoma: Based on these observations and on segregation analyses by Sanger sequencing on the rest of the family, the NM_006729.4:c.868A>G (NP_006720.1:p.I290V) variant within exon 8 of the DIAPH2 gene on chromosome X (Fig 1C, Table 1) was thus considered the most probable cause of NSHL in the family.