APOC3 and atherosclerosis: In fact, the loss-of-function mutations (R19X, IVS2 + 1G > A, and A43T) in the APOC3 gene, identified in 75,725 participants belonging to two general-population, are associated with lower circulating TG and remnant cholesterol levels (44% reduction) and with a lower burden of coronary artery calcification, which represents a surrogate marker for atherosclerosis [16].