To identify predictor factors of severity in CAD, recently Braiek AB et al. have studied a panel of biomarkers involved in atherosclerotic plaque instability and rupture including matrix metalloproteinases (MMPs) and specific tissue inhibitors (TIMPs) which controls MMP functions [51], and they conclude that ApoC-III as well as ApoC-II positively correlates with MMPs and negatively with TIMPs, thus suggesting a synergic performance of these factors in cardiovascular disorders. Here, APOC3 is linked to coronary artery disorder.