By analyzing the GEO dataset GSE137867 (https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE137867) (Fig. 1a), we identified SIGLEC9 (11729874_at) as a significantly elevated gene in ESCC tissues after radiotherapy (Fig. 1b). This evidence concerns the gene SIGLEC9 and esophageal squamous cell carcinoma.