Inhibition of cyclooxygenase-mediated production of prostaglandins, and in particular cyclooxygenase 2 (COX-2) using celecoxib, has a potent effect on both macrophage recruitment and cytokine release (Hosono et al., 2016; Majumder et al., 2014), but also an immunosuppressive effect on T cells (Iñiguez et al., 1999) that we found to be increased in advanced LM lesions in mice. The gene discussed is PTGS2; the disease is lymphangioma.