Our data show that the lipolysis genes Atgl and Hsl were significantly upregulated (Fig. 6F), while the lipogenesis-related genes Acaca and Srebp1c were significantly downregulated in the sWAT of the HDCA group of mice compared with those in the control group of mice (Fig. 6F). Here, PNPLA2 is linked to pancreatic hypoplasia-diabetes-congenital heart disease syndrome.