The dynamic levels of plasma IgM, IgA, IgG, and IgG subclasses of specific antibody responses to the SARS-CoV-2 Wuhan strain and variants in COVID-19 patients and in CoronaVac-vaccinated individuals were measured at three different time points over 28 days using enzyme-linked immunosorbent assay (ELISA). This evidence concerns the gene CD79A and COVID-19.