ACHE and Alzheimer disease: Presently, the primary therapeutic options for AD treatment are acetylcholinesterase inhibitors (AChEIs), such as donepezil, rivastigmine, galantamine, as well as the N-methyl-D-aspartate (NMDA) receptor antagonist, memantine, which can improve memory and cognitive function to a certain extent but cannot halt or reverse the progression of this disease4,.5