In the human neuroblastoma-derived SHSY5Y PD model, both tau and α-synuclein, a key pathological PD protein, were found to be hyperacetylated, which was linked to HAT p300 modulation of the deacetylase enzymes SIRT2 and HDAC6 (Esteves et al., 2019). This evidence concerns the gene EP300 and Parkinson disease.