There is growing evidence of the links between altered cytoskeletal proteins and neurodegenerative disease, including alterations to microtubule stability which can be detrimental to axonal transport, as well as impairments in actin dynamics potentially leading to altered plasticity and accumulation of intermediate filament proteins (Luo, 2002; Saha and Pahan, 2006; Kapitein and Hoogenraad, 2015; Esteves et al., 2019). The gene discussed is DNM2; the disease is neurodegenerative disease.