Studies to date have predominantly focused on the role of altered phosphorylation in neurodegenerative diseases (Hanger et al., 2009; Rudrabhatla, 2014), however, alterations in acetylation, particularly of cytoskeletal proteins, may also play a role in driving neurodegeneration (Sternberger et al., 1985; Cavallarin et al., 2010; Noble et al., 2013; Rudrabhatla, 2014; Xu et al., 2015; Schaffert and Carter, 2020). The gene discussed is DNM2; the disease is neurodegenerative disease.