TARDBP and amyotrophic lateral sclerosis: Other aggregated proteins present in the cytoplasm of induced pluripotent stem cells (iPSCs) derived from ALS patients, including TDP-43 and FUS, have also been linked with altered HDAC6 activity leading to impaired microtubule stability, ER vesicle dynamics, and mitochondria-dependent axonal transport (Fiesel et al., 2010; Guo et al., 2017; Naumann et al., 2018).