For example, in post-mortem AD tissue as well as in transgenic mouse model of tauopathy, the amino acid KXGS motif, which resides in the microtubule-binding region of tau protein was hypoacetylated which was shown to impair tau activity and result in accumulation in neurofibrillary tangles (Cook et al., 2014a). Here, MAPT is linked to Alzheimer disease.