Phosphorylation of tau and its links to neurodegenerative diseases have been extensively studied (Brotzakis et al., 2021), however acetylation of tau also occurs at the N-terminus and lysine residues and may regulate the binding of tau with microtubules (Derisbourg et al., 2015; Brotzakis et al., 2021). This evidence concerns the gene MAPT and neurodegenerative disease.