SIRT2 and Parkinson disease: In the human neuroblastoma-derived SHSY5Y PD model, both tau and α-synuclein, a key pathological PD protein, were found to be hyperacetylated, which was linked to HAT p300 modulation of the deacetylase enzymes SIRT2 and HDAC6 (Esteves et al., 2019).