Additionally, in Black/African American but not White participants, an association emerged between Hippocampal volume and sleep apnea independently (F1,38 = 4.274, p = 0.047) and the interaction between sleep apnea and APOE-e4 (F2,37 = 7.771, p = 0.002), though the association with APOE-e4 independently only trended toward significance (F2,37 = 2.476, p = 0.061). The gene discussed is APOE; the disease is sleep apnea syndrome.