Also, in White, but not Black/African American participants, APOE-e4, but not sleep apnea or their interaction continued to be associated with a higher likelihood of having mild cognitive impairment or dementia (χ2(5) = 45.663, p < 0.001), with being an APOE-e4 carrier, regardless of the number of alleles being more associated than not being a carrier (p < 0.001). This evidence concerns the gene APOE and Cognitive impairment.