Additionally, APOE-e4 (F1,1,268 = 12.324, p < 0.001) independently and the interaction of APOE-e4 and sleep apnea (F1,1,268 = 3.135, p = 0.044), but not sleep apnea independently were associated with performance on the MOCA. This evidence concerns the gene APOE and sleep apnea syndrome.