Specifically, in the total analytic sample [total sample (amyloid, n = 301), WMH, n = 197, MOCA, n = 1,266] the presence of OSA was independently associated with abnormal amyloid, and the presence of APOE-e4 alleles were associated with abnormal amyloid, as well as WMH volume, while only APOE-e4 was independently associated with performance on the MOCA and cognitive status in this sample. Here, APOE is linked to obstructive sleep apnea syndrome.