MAPT and Alzheimer disease: When classifying cognitively unimpaired participants into preclinical AD stages: Aß-negative/p-tau-negative, Aß-positive/p-tau-negative, and Aß-positive/p-tau-positive, individuals with the Aß+/p-tau– revealed cortical thickening in the middle temporal, superior and inferior temporal, and lateral occipital regions compared with the Aß−/p-tau– group, but the Aß+/p-tau+ group showed relatively thinner cortex in these brain regions than the Aß−/p-tau– group (Fortea et al., 2014; Montal et al., 2018).