Moreover, the lateral temporal cortex and inferior parietal cortex are included in the AD cortical signature that is associated with AD symptoms severity, tau pathology and a risk of progression to AD (Bakkour et al., 2009; Dickerson et al., 2009; McEvoy et al., 2009; Wang et al., 2015), which is in line with the our finding of a higher risk of progression to AD in the complex group. This evidence concerns the gene MAPT and Alzheimer disease.