Some scholars found no axonal and astrocyte damage and typical demyelination changes in the brain specimens of two patients with cortical encephalitis (Patterson et al., 2019), and CSF binding MBP, a marker of astrocyte damage, was not increased in patients with cortical encephalitis in the case of extensive cortical involvement and CSF pleocytosis (Ogawa et al., 2017). This evidence concerns the gene MBP and viral encephalitis.