However, MOG has been established as an antigenic target in animal models of experimental autoimmune encephalomyelitis, and relevant studies proposed that MOG antibodies are involved in the pathogenesis of inflammatory demyelinating disease as revealed by animal models (Merkler et al., 2006; Reindl et al., 2013; Ramanathan et al., 2016; Stassart et al., 2016). Here, MOG is linked to experimental autoimmune encephalomyelitis.