The NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome plays an important role in the canonical pyroptosis pathway, which is associated with neurodegenerative diseases, such as AD, Parkinson’s disease, and epilepsy (Moujalled et al., 2021; Xia et al., 2021), and is a pivotal role in PNDs (Zhang et al., 2021b). The gene discussed is NLRP3; the disease is Alzheimer disease.