APOE and cardiovascular disorder: Given the association between L-carnitine gut-related metabolites and APOE with cardiovascular disease, we investigated the effect of different APOE genotypes on the metabolism of L-carnitine, acylcarnitines, and other metabolites capable of producing TMA and TMAO (TMA-containing metabolites) to investigate whether changes in TMA/TMAO could be associated with either L-carnitine or other metabolites capable of producing these metabolites after an L-carnitine challenge.