The impairment in the reward conflict test observed in male and female Fmr1-KO mice cannot simply be explained by a more general increase in “anxiety” or decrease in motivation because Fmr1-KO mice showed similar performance as WT mice in the elevated-plus maze test and Fmr1-KO mice were just as likely to consume a cereal piece when they entered an open arm as WT mice. The gene discussed is FMR1; the disease is Anxiety.