However, it is known that paclitaxel and vincristine-induced neuropathy trigger significant inflammatory processes which are less evident with oxaliplatin-induced neuropathy, mainly arising from the enhanced release of proalgesic mediators such as TNF and IL-1β by activated microglia, astrocytes and satellite glial cells within the dorsal horn of the spinal cord (179). This evidence concerns the gene IL1B and neuropathy.