BCHE and Alzheimer disease: In order to find natural lead compounds for the treatment of Alzheimer’s disease, benzofurans, as an important pharmacophore, have received extensive attention in the past few years because of their attractive cholinesterase inhibitory activity (Rizzo et al., 2012; Khanam and Shamsuzzaman, 2015; Delogu et al., 2016; Wang et al., 2017).