TNF and small cell lung carcinoma: Several recent preclinical studies demonstrated the striking potency of various chemotherapeutic agents such as PEN-866, EC145, AEZS-108, NGR-TNF (Asn-Gly-Arg-TNFa), and EC0225 in xenograft models of solid tumours including breast, pancreatic, and small cell lung cancer in xenograft models of solid tumours including breast, pancreatic, and small cell lung cancer (SCLC) (Patel et al., 2021).