Several recent preclinical studies demonstrated the striking potency of various chemotherapeutic agents such as PEN-866, EC145, AEZS-108, NGR-TNF (Asn-Gly-Arg-TNFa), and EC0225 in xenograft models of solid tumours including breast, pancreatic, and small cell lung cancer in xenograft models of solid tumours including breast, pancreatic, and small cell lung cancer (SCLC) (Patel et al., 2021). This evidence concerns the gene RTN4R and small cell lung carcinoma.