The RNA-seq results from Fsmo;hGFAP-Cre medulloblastomas showed significant downregulation of histone acetyltransferases (HAT: Hat1 and Kat2a/GCN5), the histone deacetylase (HDAC) Hdac1, and the histone acetylation reader Brd2 between vehicle- and LDE-treated samples (Fig. 3B and C; Supplementary Fig. S2F–S2H). This evidence concerns the gene TMPRSS11D and medulloblastoma.