HDAC1 and medulloblastoma: A previous study reported that transformed Smo/Smo medulloblastoma tissues have increased HDAC1, HDAC2, and HDAC3 and decreased HDAC11 expression compared with wild-type or untransformed Smo/Smo cerebellum tissues (46), suggesting that dysregulated histone acetylation may be integral to medulloblastoma formation.