Interestingly, the Kat2b/PCAF, HDAC5, 7, and 11 RNA levels were increased in resistant tumors, and the RNA level of Brd4, previously reported to mediate SMOi resistance in SHH MBs by upregulating Gli1 expression (40), was not significantly altered (Fig. 3B and C). This evidence concerns the gene BRD4 and Mobius syndrome.