PTCH1 and medulloblastoma: H3K9Ac, H3K14Ac, H3K56Ac, H4K5Ac, and H4K8Ac marks were significantly reduced in both FSmoM2;hGFAP-cre and Ptch;p53 SI-CSC medulloblastoma mouse models treated with LDE225 (Fig. 5A and B).