Notably, this response was not an acute response to SMOi treatment, because short-term (up to 24 hours) LDE225 treatment did not reduce the protein levels of HATs or HDACs (Fig. 4H), indicating that these changes are adaptative mechanisms to chronic SMOi exposure and likely contribute to deviations from generating SHH-dependent CGPs in LDE225-resistant SI-CSC medulloblastomas. Here, SHH is linked to medulloblastoma.