Specifically, we tested whether SMOi-resistant tumors containing SHH-dependent CSCs (SD-CSC) acquire new mutations in the SHH pathway, while SHH medulloblastomas containing SHH-independent CSCs (SI-CSC), that is, SI-CSC medulloblastomas, do not (Fig. 1A). The gene discussed is SHH; the disease is medulloblastoma.