Although it has been reported that constipation can change the composition of gut microbiota (13), several studies have shown that constipation could be relieved by regulating the intestinal microbiota and the metabolites (14), promoting gut-brain communication (15), and enhancing the intestinal peristalsis via the c-Kit pathway of interstitial cells of Cajal (ICCs) (9). The gene discussed is KIT; the disease is constipation disorder.