Indeed, if colitis is not massively increased (no significant changes of the survival curves, the weight loss or the intestinal transit at day 18, the micro-DAI, the Lcn-2 faecal concentration or the global gene expression) the P + DSS group showed some exacerbated responses to DSS (transient changes in weight loss and transit time, an increase in DAI and faecal humidity) via modification of the distal colonic luminal microbiota composition and changes in distal colonic lipid content. Here, LCN2 is linked to colitis.