INS and obesity due to melanocortin 4 receptor deficiency: In addition, it has been reported that Blautia is a common acetic acid producer in the intestine, which may inhibit insulin signaling in adipocytes by activating the G protein-coupled receptors GPR41 and GPR43, thus promoting the metabolism of unbound lipids and glucose in other tissues, and consequently alleviating obesity-related diseases such as type 2 diabetes.