SELENOI and Spastic paraplegia: Dysfunction in the CDP-Etn branch of the Kennedy pathway has recently been linked to hereditary spastic paraplegia (OMIM #618768-Spastic paraplegia 81, autosomal recessive; SPG81 and OMIM#618770-Spastic paraplegia 82, autosomal recessive; SPG82) (8) and childhood-onset neurodegeneration named CONATOC (OMIM #618868—Neurodegeneration, childhood-onset, with ataxia, tremor, optic atrophy and cognitive decline; CONATOC) (9).