For instance, NOS2 may reduce HF (Cinar et al., 2016; Shen et al., 2017; Becerril et al., 2019) and liver injury (Li D. et al., 2020) by reducing inflammatory responses, and studies has shown that NOS2 may reduce inflammatory bowel disease and maintain gut microbial homeostasis (Matziouridou et al., 2018). The gene discussed is NOS2; the disease is inflammatory bowel disease.