Moreover, deoxypodophyllotoxin has also been confirmed to mediate the intrinsic mitochondrial pathway to induce CRC cell apoptosis by increasing the level of pro-apoptotic protein Bax and decreasing the level of anti-apoptotic protein Bcl-xL (Gamage et al., 2019), which was not involved in our study and can be carried out in subsequent studies. The gene discussed is BCL2L1; the disease is colorectal carcinoma.