KEGG analysis showed that the dysregulation of the TNF, NF-kB, and MAPK signaling pathways, altered levels of cancer-related miRNAs, and changes in the expression of genes mediating transcriptional misregulation in cancer were likely involved in the biological mechanism by which plantaricin BM-1 induced apoptosis in SW480 cells. This evidence concerns the gene NFKB1 and cancer.