In the T cell proliferation experiment, CD66b+CD10+-NDN in healthy volunteers had no effect on lymphocyte proliferation, CD66b+CD10+/–-NDN and CD66b+CD10+-LDN in sepsis patients inhibited lymphocyte proliferation; on the contrary, CD66b+CD10–-LDN in sepsis patients enhanced lymphocyte proliferation. The gene discussed is MME; the disease is Sepsis.