The incidence rate of severe hypoglycemia in persons with type 2 diabetes is approximately 0.1–0.7% (19) or 0.05 episodes per 100 patient-years (20); it is 0.8 (or 0.9 events per 100 patients-years) (21) to 7% (10 episodes per 100 patient-years) in T2D patients on sulfonylurea (19, 20) and 1.2–7.3% (or 11.8 episodes per 100 patient-years) (20) in patients with T2D on insulin (19, 21). This evidence concerns the gene INS and Hypoglycemia.