The forest plot of subgroup analysis of hypoglycemia risks in patients with cirrhosis versus without cirrhosis showed no significant interaction in the risk factors of age, sex, CKD, sulfonylurea, glibenclamide, glipizide, gliclazide, glimepiride, number of oral hypoglycemic agents, insulin, β-blocker, and fibrate (Figure 4). This evidence concerns the gene INS and Cirrhosis.