Interestingly, 4 of the 10 pairwise common loci had different pleiotropic directions: IL1R2 on chromosome 2 and HIST1H2BO on chromosome 6 were antagonistic for Parkinson’s disease-Crohn’s disease but concordant for Parkinson’s disease-UC, while EFNA3 on chromosome 1 and IP6K2 on chromosome 3 were ambiguous for Parkinson’s disease-Crohn’s disease but affected Parkinson’s disease-UC in opposite and same directions, respectively. This evidence concerns the gene IP6K2 and Crohn disease.