In line with these findings, in a recent study, wherein we have compared Alzheimer’s disease, dementia with Lewy body and Parkinson’s disease with dementia patients to early preclinical patients with SCD who do not have any detectable objective cognitive or pathological alterations, we have found elevated ZnT3, Dyn1 and GluA3 concentrations. This evidence concerns the gene GRIA3 and early-onset autosomal dominant Alzheimer disease.