Another significant finding of this study is the striking resemblance found in the CSF synaptic profile of the patient cohort and the App knock-in Alzheimer’s disease mice, especially the AppNL-G-F mice that exhibit a stronger pathology compared with the AppNL-F mice exhibit significantly elevated GluA3 and a trend towards increased Dyn1 concentrations in CSF. This evidence concerns the gene GRIA3 and early-onset autosomal dominant Alzheimer disease.