In this study, we have compared the extent of synaptic changes as reflected by the concentrations of three synaptic proteins (ZnT3, Dyn1, GluA3), previously found to be associated with cognitive impairment and Alzheimer’s disease pathology.18,35 We have assessed their concentrations in CSF and brains of Alzheimer’s disease animal models as well as in CSF of Alzheimer’s disease, MCI and cognitively and neurologically healthy controls. The gene discussed is GRIA3; the disease is early-onset autosomal dominant Alzheimer disease.