GRIA3 and early-onset autosomal dominant Alzheimer disease: Hippocampal and the prefrontal cortical regions were more closely investigated in our study based on their early involvement in Alzheimer’s disease, but also because of their essential functional interaction in the encoding and retrieval of working, emotional and episodic memory.49 Apart from the hippocampus, GluA3 is present throughout the cortical and subcortical structures50 suggesting its importance in synaptic plasticity.