In the case of Alzheimer’s disease, the highest area under the curve (AUC) was observed for GluA3 equal to 0.98 (sensitivity 94%, specificity 100%), 0.85 AUC for Dyn1 (sensitivity of 67% and specificity of 94%) and 0.88 AUC (sensitivity of 83% and specificity of 89%) in the case of ZnT3 (Table 2, Supplementary Fig. 1). This evidence concerns the gene SLC30A3 and early-onset autosomal dominant Alzheimer disease.