These increased CSF ZnT3 concentrations were associated with cognitive impairment in Alzheimer’s disease.35 While the individual diagnostic utility of these proteins was moderate when differentiating SCD patients from other dementias (∼0.7 AUC),18 control patients were differentiated with an excellent 0.8–0.95 AUC from Alzheimer’s disease or MCI in our current study. This evidence concerns the gene SLC30A3 and dementia.