In a translational approach, we investigated the changes of the three synaptic proteins upon progression of the pathologies in two App knock-in mice, AppNL-F and AppNL-G-F, exhibiting robust Aβ pathology, neuroinflammation and cognitive impairments, by assessing the concentrations of ZnT3, Dyn1 and GluA3 in 24-month-old AppNL-F and AppNL-G-F mice compared with age matched Appwt mice by ELISA. This evidence concerns the gene SLC30A3 and Cognitive impairment.