In the current study, we investigated the effect of a novel chalcone derivative with the chemical name 1-(4-(methylsulfonyl)phenyl)-3-(phenylthio)-3-(p-tolyl)propane-1-one abbreviated as MPP, alone or combined with curcumin, on the NF-κB signaling pathway, in two different cancer cell lines including MDA-MB-231 triple-negative breast cancer cell line and the SKOV3 ovarian cancer cell line. Here, NFKB1 is linked to ovarian carcinoma.