circSMARCA5 was selected as the research object in this study to explore the role of circSMARCA5/miR-582-3p/PTEN in modulating NPC development mechanisms and action covering epithelial-mesenchymal transition (EMT), proliferation, migration, invasion, and apoptosis to provide new targets and insights for NPC therapy and diagnosis. This evidence concerns the gene PTEN and nasopharyngeal carcinoma.