Based on the distinct role of PTEN in modulating the PI3K/Akt/mTOR pathway and the pathway in cell survival and proliferation, in numerous researches, PTEN's action in cancer is explored, such as LC [43], colon cancer [44], bladder cancer [45], etc. PTEN's action in NPC has also been figured out. This evidence concerns the gene AKT1 and laryngotracheoesophageal cleft.