Our previous clinical results indicated that the combination of the Luhong formula with the standardized treatment of modern medicine significantly improved the Minnesota Living with Heart Failure Questionnaire (MLHFQ) score of patients and significantly inhibited the serum levels of profibrotic factors (TGFβ1, CTGF) and collagen (type I collagen and type III collagen) [29, 30]. Here, CCN2 is linked to heart failure.