The KEGG pathway enrichment analysis revealed 184 signaling pathways involved in treating OP with GBZGG, majorly playing a role in treating OP by regulating the fluid shear stress and AGE-RAGE, prostate cancer, IL-17, TNF, hepatitis B, PI3K-AKt, MAPK, and other signaling pathways of atherosclerosis and diabetic complications, as shown in Figure 9 and Supplementary 8. Here, RENBP is linked to atherosclerosis.