IGHE and Hypertension: Diagnosed nonopioid analgesic hypersensitivity was significantly associated with atopic dermatitis (OR 10.28, AME +28.5%), elevated IgE 200–1,000 kU/L (OR 4.95, AME +25.1%), and arterial hypertension (OR 4.53, AME +18.5%) (Table 1).